Pathophysiology of diaphragm fatigue in patients with systolic heart failure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016544

Enrollment

Registered

2019-01-09

Start date

2019-01-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I50.1

Interventions

Group 1: 10 patients with systolic heart failure will undergo placement of intraesophageal and intragastral balloon catheters in order to continuously record trans-diaphragmatic pressure after magneti

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: a. Age > 18 years (no age limit) b. able to consent c. Diagnosis of systolic heart failure in accordance with the latest available ESC/HF (European Society of Cardiology - Heart Failure) guideline (Ponikowski et al. 2016) (HFrEF)

Exclusion criteria

Exclusion criteria: - Severe psychiatric disease including dementia - Thoracic wall disease - Cardiac pacemaker

Design outcomes

Primary

Measure	Time frame
Twitch trans-diaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [cmH2O] (on the day of the appointment in our laboratory and before, during and after diaphragm fatigue has been reached)	—

Countries

Germany

Contacts

Public ContactIzabela Tuleta

Klinik für Kardiologie I

izabela.tuleta@ukmuenster.de0251-83-46760

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026