G35.0
Conditions
Interventions
Group 1: 1) Pediatric MS patients. We will analyze brain biopsies that were taken for diagnostic purposes. Our focus will be CNS de- and regeneration as well as inflammation. In addition we will analy
Sponsors
Universitätsmedizin Göttingen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with brain biopsies taken for diagnostic reasons with 1) pediatric MS patients, or 2) patients with late onset MS (= 50 years) or 3) control patients (disease onset at the age of 20-40 years).
Exclusion criteria
Exclusion criteria: MRI studies: 1) Female subjects who are currently pregnant 2) Known history of sensitivity to gadopentate or mannitol 3) Metallic device which is known to interfere with magnet 4) Known history of claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint are histopathological characteristics that will be determined in pathological samples (after performing histological/immunohistochemical stainings the number of inflammatory cells, the axons, acutely damaged axons and oligodendrocytes will be quantified using the microscope). A semiquantitative analysis of the remyelination will be performed. Results of the different groups will be compared with statistical methods. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point: Histopathological results will be correlated with clinical (relapse rate, disease course, EDSS) and MRI parameters (T2 lesion load, T1 hypointense lesions, Gd-enhancing lesions). | — |
Countries
Germany
Contacts
Public ContactImke Metz
Institut für Pathologie, Universitätsmedizin Göttingen
Outcome results
None listed