F33.2 F51.0
Conditions
Interventions
Group 1: In MDD patients prior to and following implantation of vagal nerve stimulation LC function will be assessed using REM sleep parameters, pupillometry and reaction to acustically evoked potenti
Sponsors
Klinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: •Ability to provide written informed consent •Patients with MDD, eligible for and scheduled for treatment with VNS or Patients with ID or healthy controls
Exclusion criteria
Exclusion criteria: •Acute suicidal ideations •Ongoing substance abuse •For controls: current relevant psychiatric (for ID patients other than ID) or somatic disorder or recurring psychiatric disorder in the past •Somatic medication potentially confounding outcome variable besides stable psychiatric medication in patients with MDD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a)REML, REM (min), REM (%), REMD, EOGS, REM cycles b)P3 amplitude, baseline pupil diameter c)Change in BDI/HAMD/MADRAS baseline/12/18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| a) NREM sleep parameters b) Spectral EEG sleep parameters c) Wake spectral EEG parameters d) Stimulation intensities e) Subjective assessments of sleep and depression f) Comparison to healthy controls and patients with insomnia disorder | — |
Countries
Germany
Contacts
Public ContactLukas Frase
Klinik für Psychiatrie und Psychotherapie
Outcome results
None listed