The impact of opioid-free anesthesia on the incidence of postoperative nausea and vomiting after gynecological laparoscopy

The impact of opioid-free anesthesia on the incidence of postoperative nausea and vomiting after gynecological laparoscopy - OF-DoSe (Evaluation of opioid-free anesthesia with Dexmedetomidine and S-Ketamine)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016527

Enrollment

152

Registered

2019-01-11

Start date

2019-01-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OPS-2018 1-694 (Diagnostic laparoscopy (peritoneoscopy)) R11

Interventions

Group 1: Control group: General anesthesia including opioids as analgesic component Group 2: Intervention group: opioid-free anesthesia including adjuvants as analgesic component

Eligibility

Sex/Gender

Female

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -female sex -age >18years

Exclusion criteria

Exclusion criteria: -chronic pain -allergies or contradictions against the used anesthetic agents -pregnant or breastfeeding women

Design outcomes

Primary

Measure	Time frame
incidence of PONV up to 24h post-op	—

Secondary

Measure	Time frame
1. severity of PONV (simplified PONV impact scale, Myles et al (2012)) 2. postoperative opioid requirement 3. pain severity (NRS-Score) 4. postoperative recovery time 5. patient satisfaction 6. incidence of anesthesia awareness	—

Countries

Germany

Contacts

Public ContactManuel Wenk

Universitätsklinikum Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

manuelwenk@uni-muenster.de0251 / 83 472 52

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026