Mapping the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging

Mapping the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging - ESOMAP Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016367

Enrollment

Registered

2019-01-04

Start date

2019-12-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C15.5

Interventions

Group 1: Patients with distal esophageal cancer or esophagogastric junction cancer (cancer of the cardia) scheduled for esophagectomy will be enrolled in this study. Before surgery, an endoscopy will

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with clinically advanced stage adenocarcinoma of the esophagus (T2-T4, N0-N3) undergoing surgical resection

Exclusion criteria

Exclusion criteria: Patient refuses intervention

Design outcomes

Primary

Measure	Time frame
Patients will undergo laparoscopic mobilization of the stomach and abdominal lymphadenectomy, followed by transthoracic thoracoscopic or open esophagectomy and thoracic lymphadenectomy using fluorescence imaging as a guide for complete lymph node dissection and to preserve the lymphatic channels. Affected nodes as detected by fluorescence imaging will be marked and dissected separately for later histopathological workup. Primary endpoint will be therefore the visualization of lymphatic channels along first and second tier nodes during the surgery.	—

Measure

Time frame

Patients will undergo laparoscopic mobilization of the stomach and abdominal lymphadenectomy, followed by transthoracic thoracoscopic or open esophagectomy and thoracic lymphadenectomy using fluorescence imaging as a guide for complete lymph node dissection and to preserve the lymphatic channels. Affected nodes as detected by fluorescence imaging will be marked and dissected separately for later histopathological workup. Primary endpoint will be therefore the visualization of lymphatic channels along first and second tier nodes during the surgery.

—

Secondary

Measure	Time frame
Pattern of lymph nodes metastatic spread of advanced esophageal Cancer along lymphatic channels (proximal to distal from the Tumor or has direct communication with distal nodes or multidirectional resulting skip metastasis). Visualization during surgery.	—

Countries

Germany

Contacts

Public ContactHans Fuchs

Klinik und Poliklinik für Allgemein-, Viszeral- und TumorchirurgieUniklinik Köln

hans.fuchs@uk-koeln.de+49-221-478-4801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026