Longitudinal change and cardiovascular (CV) impact of blood pressure adjusted pulse wave velocity in patients with advanced chronic kidney disease

Longitudinal change and cardiovascular (CV) impact of blood pressure adjusted pulse wave velocity in patients with advanced chronic kidney disease - no acronym

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016291

Enrollment

400

Registered

2019-01-14

Start date

2019-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I70.9 N18.3 N18.4 N18.5

Interventions

Group 1: observational study design: At baseline and 24 months later we will perform an ambulatory blood pressure monitoring (ABPM) with pulse wave analysis. This will be performed over 24 hours in n

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Presence of advanced chronic kidney disease (CKD) defined as estimated glomerular filtration rate (eGFR) <45 ml/min/1,73 m2 according to creatinine-based CKD-EPI formula or patients on dialysis • At least one valid long-term BP-recording and pulse wave analysis (at least 20 hours or at least 38 hours for the study participants on dialysis with at least 70% valid measurements); • Subjects willing and able to provide informed consent; • Dialysis patients must be at least one year on dialysis; • Assumed life expectancy at least one year

Exclusion criteria

Exclusion criteria: • Arrhythmias, which make oscillometrical BP-measurement or pulse wave analysis impossible; • Age<18 years; • Stenosis located proximately to or at the measurement point; • Myocardial infarction, stroke or invasive CV intervention in the last three months; • Subject not able or willing to give informed consent; • Hospital stay in last four weeks

Design outcomes

Primary

Measure	Time frame
number of cardiovascular events after 24 months in association with blood pressure adjusted PWV (Pulse wave velocity): The PWV will be adjusted to the 120 mmHg central blood pressure (PWV120). Afterwards, quartiles of PWV120 will be made and the incidence of cardiovascular events in the quartiles will be observed during follow-up	—

Secondary

Measure	Time frame
1. Trajectories of longitudinal change in blood pressure adjusted PWV during follow up 2. At least 0.5 m/s higher PWV120cSBP in study patients compared with subjects from extern collective with moderate cardiovascular risk	—

Countries

Germany

Contacts

Public ContactAlexander Reshetnik

Klinik für Nephrologie Campus Benjamin Franklin Charité Universitätsmedizin Berlin

alexander.reshetnik@charite.de004930450514552

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026