F42.2 F42.0 F42.1
Conditions
Interventions
Group 1: adaptive cognitive training (3 weeks 5x per week) for ca. 30 minutes), subsequently: cognitive behavioral therapy
Group 2: non-adaptive cognitive training (3 weeks 5x per week) for ca. 30
Sponsors
Humboldt-Universität zu Berlin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ICD10, F42 (Obsessive-compulsive disorder)
Exclusion criteria
Exclusion criteria: The following exclusion criteria will be applied to all patients (current and life-time): Co-morbid substance-related disorders, schizophrenia spectrum disorders, delusional disorders, bipolar disorder, neurological disorders of the CNS, verbal IQ < 85. Furthermore, benzodiacepines within the last week, neuroleptics during the last three months will lead to an exclusion. Exclusion criteria for healthy controls (current and life-time): any mental disorders according to DSM-5, neurological disorders of the CNS, verbal IQ < 85. Furthermore, benzodiacepines within the last week, neuroleptics during the last three months will lead to an exclusion. All participants must be able to be tested in an MRI, have no disabilities in speaking and must not have any uncorrectable seeing or hearing impairments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Performance (reaction times and error rates) and neuronal activation patterns (blood-oxygen-level-dependent signal) in working memory, measured with functional Magnetic Resonance Imaging (fMRI) during n-back task at measurement time t1 (before training) and t2 (after training). • Performance (reaction times and error rates) and event-related potentials in performance monitoring measured with electroencephalography (EEG) during Flanker task at measurement time t1 and t2. | — |
Secondary
| Measure | Time frame |
|---|---|
| All measurements at t1 and t2: • OCD (Obsessive-Compulsive Disorder) symptoms measured with SCID-I OCD section, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Obsessive-Compulsive Inventory-Revised (OCI-R) • Depressive symptoms measured with Beck Depression Inventory II (BDI-II) and Montgomery Asberg Depression Rating Scale (MADRS) • Additional questionnaires: Brief Symptom Inventory (BSI), Beck Anxiety Inventory (BAI), Fragebogen zu exekutiven Funktionen (KATE), Emotion Regulation Questionnaire (ERQ) • Neuropsychological tests: Stroop, Digit Symbol, Digit span, Leistungsprüfsystem – Subtest Figural relations, Trail making test A & B | — |
Countries
Germany
Contacts
Public ContactRosa Grützmann
Klinische Psychologie, Institut für Psychologie, Humboldt-Universität zu Berlin
Outcome results
None listed