Assessment of the functional state and Serum concentrations of pro- and anti-inflammatory mediators in individuals with grief and complicated grief.

Assessment of the functional state and Serum concentrations of pro- and anti-inflammatory mediators in individuals with grief and complicated grief. - GRIF Study (Grief and Inflammation)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016160

Enrollment

100

Registered

2018-12-14

Start date

2018-12-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F43 F33

Interventions

Group 1: This study approaches to quantify changes in concentrations of inflammatory mediators (serum/saliva) using enzym-linked immuno-assayand to determine possible relationships between molecular c

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18-75 years Relative of patients of the palliativ care unit Willigness to participate in the study

Exclusion criteria

Exclusion criteria: Neurological disorders - substance abuse - psychiatric disorders - cardiovascular disorders - malignancy - pregnancy - acute/chronic infections - between 18-75 years

Design outcomes

Primary

Measure	Time frame
Concentration changes of pro- and anti-inflammatory marker in serum and saliva will be determined using enzym-linked immuno Assay (ELISA). Saliva and Serum samples will be collected between 08.00-10.00 am within the study period (2 time points).	—

Secondary

Measure	Time frame
Correlation with changes of the functional state of the grief participants.	—

Countries

Germany

Contacts

Public ContactLukas Radbruch

Klinik für Palliativmedizin

lukas.radbruch@ukb.uni-bonn.de+49 (0)228 287 13495

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026