E83.30: Familial hypophosphatemic rickets
Conditions
Interventions
Group 1: 10 adult patients with X-linked hypophosphatemia with oral phosphate Supplementation
Tests:
1. Baseline blood samples (15 min)
2. Isokinetic fatigue test (30 min)
3. Recovery break, with blo
Sponsors
DLR- Deutsches Zentrum für Luft- und Raumfahrt - Institut für Luft- und Raumfahrtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Patients with diagnosed phosphate diabetes with and without Phosphate medication - healthy adults with low physical activity - signed informed consent
Exclusion criteria
Exclusion criteria: - any injury or acute or chronic disease that would not allow performing the calf muscle test or the jump test - any indications against the MRI/MRS examinations, such as claustrophobia, metal implants, pacemakers, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle fatigue, assessed as percent decrease in maximum torque during 20 repetitions of continuous voluntary isokinetic plantar flexions in an angular velocity of 60 deg/s | — |
Secondary
| Measure | Time frame |
|---|---|
| - maximum voluntary torque (MVC) at the first contraction of the fatigue test - 31P-MRS at rest: levels of phosphocreatine (PCr), inorganic phosphate (Pi) and ATP in soleus and gastrocnemius medialis muscles - MRI at rest: volumes of the triceps surae muscles and the quadriceps muscles normalized to body weight and body size | — |
Countries
Germany
Contacts
Public ContactJörn Rittweger
Institut für Luft- und Raumfahrtmedizin,Deutsches Zentrum für Luft- und Raumfahrt (DLR)
Outcome results
None listed