C41.9 C41
Conditions
Interventions
Group 1: Patients will be selected according to the inclusion criteria after examination at the LMU Clinic and Polyclinic, informed about the procedure at least 24h before the examination. Imaging suc
Sponsors
Klinikum der Universität München, Campus Großhadern
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Soft tissue sarcoma of the extremities in tumor stage AJCC III with indication for neoadjuvant combined chemotherapy/hyperthermia - Tumor board decision for treatment chemotherapy/hyperthermia - Indication for MRI and PET-CT examinations as part of clinical care for soft tissue sarcoma - > 18 years male/female - GFR value >30ml/min - Signed declaration of consent
Exclusion criteria
Exclusion criteria: - Contraindications to MRI examination, especially implants not suitable for MR, tattoos or piercings, pronounced claustrophobia - Lack of consent and/or lack of ability to consent to the study - Pregnancy - Known allergy to MR contrast agent or PET-CT tracer - GFR < 30 ml/min with renal insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of tumor response during neoadjuvant chemotherapy/thermotherapy using dynamic contrast-enhanced as well as diffusion-weighted MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. prediction of progression-free survival using DCE-MRI and DWI. 2. comparison and correlation of DCE-MRI and DWI to PET-CT. | — |
Countries
Germany
Contacts
Public ContactChristel Besseler
Klinik und Poliklinik für Radiologie Klinikum der Universität München Campus Großhadern
Outcome results
None listed