No illness or health problem is investigated, only the effects of local anesthesia on different nerve fibers are examined
Conditions
Interventions
Group 1: T0: 2% Lidocaine without adrenalin (1ml)
T30: Injection with sodium chloride (1ml)
Group 2: T0: 2% Lidocaine with adrenalin 1:100.000 (1ml)
T30: Injection with sodium chloride (1ml)
Group 3:
Sponsors
Ressort Forschung und Lehre der Universitätsmedizin Mainz
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - Age 18-40 years - Belonging ASA risk group 1, no general conditions - Body weight = 50kg - No use of permanent or acute medication - No alcohol, nicotine or coffee consumption in the last 24 hours before examination - No pain symptoms in the maxillary anterior region in the last 6 months - No dental therapy in the maxillary anterior region before the examination - No indication of neurological or psychiatric disorders - No diseases affecting the somatosensitive system - No known allergies / hypersensitivity reactions to the test substances used - Response to the local anesthetic - Non smoking - No chronic alcohol consumption - good compliance - Sufficient knowledge of German - Maxillary Canines - Clinically and anamnestically unremarkable, caries-free and filling-free, vital - Parodontium in the maxillary canine region free of inflammation - Written agreement to participate
Exclusion criteria
Exclusion criteria: - ASA Risk Group II-IV - Present contraindications for topical anesthetics, epinephrine or Phentolamine mesilate - Known allergies / hypersensitivity reactions to the test substances used, including allergy to sodium sulphite (antioxidant) - Failure to respond to the respective local anesthetic - Nicotine abuse, alcohol dependence - Persistent pain in the last 6 months - Any kind of general diseases - Regular / acute medication - History of previous problems with dental local anesthesia - Filled / carious / non-sensitive maxillary canines - Local inflammatory conditions and mucosal lesions of the oral cavity (such as gingivitis, parodontitis, leukoplakia, oral lichen planus, pemphigus vulgaris) or the skin in the test area - Reference data for the lip when collecting the first QST finding - lack of understanding of the necessary cooperation in the tests - Scar in the test area - Withdrawal of consent by the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decay the local anesthetic solution and attainment of initial values t8: 220min after injection of the local anesthetic solution (will not be achieved by all subjects) | — |
Secondary
| Measure | Time frame |
|---|---|
| Termination of the standardized test series (including QST) Total decay of local anesthesia and recovery of initial values | — |
Countries
Germany
Contacts
Public ContactJelena Zahn
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie- Plastische Chirurgie
Outcome results
None listed