H90.1 H90.2
Conditions
Interventions
Group 1: 20 asymmetric hearing impaired (AHL) patients
Patients and subjects in the control group are tested in four different situations during fMRI. An fMRI image is taken without stimulation. In a
Sponsors
HNO-Uniklinik Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: AHL patients - Hearing ability of the poorer ear: severe hearing loss up to hearing loss bordering on deafness. - Hearing ability of the better ear: air conduction hearing threshold in the range up to and including 4 kHz of > 30 dB HL and = 60 dB HL - Preferred AHL patients who have received an [18F]FDG PET image due to a clinical indication with good image quality. NH subjects - Hearing in both ears: Air conduction hearing threshold in the 125-8000 Hz range of = 20 dB HL - Speech intelligibility threshold in Oldenburg sentences test for S0N0 (fixed noise level of 65dB SPL and a start speech level of 65dB SPL) - Monaural left: = -6 dB - Monaural right: = -6 dB - Binaural: = -6 dB
Exclusion criteria
Exclusion criteria: All Groups - Age 65 years - Left-handers (Edinburgh Handsiness Inventory: Laterality Quotient< 60) - relevant neurological or psychiatric concomitant disease (e.g. cognitive impairment, epilepsy, cerebrovascular disease, brain tumor, depression, etc.) - Diseases that may be expected to lead to inadequate compliance with fMRI (e.g. back pain, severe claustrophobia, incontinence, metal implants, etc.) - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In AHL patients, fMRT signal changes in the primary auditory cortices and inferior colliculi (regions-of-interest, ROIs) will be compared between resting and with acoustic, visual, and sensorimotor stimulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison of fMRT signal changes of ROIs, primary auditory cortices and inferior colliculi, between AHL patients and age-matched NH controls - In AHL patients: Comparison of fMRT signal changes in ROIs with the signal changes of cerebral glucose metabolism in ROIs in [18F]FDG-PET scans | — |
Countries
Germany
Contacts
Public ContactIva Speck
HNO-Uniklinik Freiburg
Outcome results
None listed