Pathophysiology of diaphragm fatigue in patients with Amyotrophic lateral sclerosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016013

Enrollment

Registered

2018-11-20

Start date

2018-11-28

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G12.2

Interventions

Group 1: 10 patients with Amyotrophic lateral sclerosis will undergo placement of intraesophageal and intragastral baloon catheters in order to continuously record trans-diaphragmatic pressure after m

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: a. Age > 18 years (no age limit) b. able to consent c. likely or definite diagnosis of Amyotrophic lateral sclerosis accoring to the revised El-Escrial criteria

Exclusion criteria

Exclusion criteria: - other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe endstage renal impairment - severe neurological pre-existing conditions, especially brainstem infarction - intake of opioids - severe psychiatric pre-existing conditions

Design outcomes

Primary

Measure	Time frame
Twitch transdiaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [cmH2O]	—

Countries

Germany

Contacts

Public ContactMatthias Boentert

Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster

matthias.boentert@ukmuenster.de00492518344458

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026