Z94.2 J44.9
Conditions
Interventions
Group 1: 20 Lung transplant recipients will undergo a comprehensive and unique set of lung function and respiratory muscle strength tests within our lab of respiratory physiology.
This will be done at
Sponsors
Institut für Schlafmedizin und neuromuskuläre Erkrankungen, Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Age > 18 years (no age limit) b. able to consent c. chronic lung disease with lung transplantation
Exclusion criteria
Exclusion criteria: - other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe endstage renal impairment - severe neurological pre-existing conditions, especially brainstem infarction - intake of opioids - severe psychiatric pre-existing conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Twitch transdiaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [cmH2O] | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Severity Scale [points], quality of life using SF-36 [points], six-minute walk distance (6 MWD) [m], Medical Research Council Dyspnoea Scale [points], Borg Dyspnoea Scale pre and post 6 MWD [points], -> the above mentioned values will be obtained by means of questionaires handgrip muscle strength [kg], -> the above mentioned value will be obtained by means of a dynamometer Forced vital capacity [ml], FEV1/FVC [%], MIP [cmH2O], MEP [cmH2O], peak cough Flow [L/sek], -> the above mentioned values will be obtained by means of spirometry devices Rate of rise of diaphramatic amplitude during tidal breathing on ultrasound [cm/sec], Rate of rise of diaphramatic amplitude during Sniff maneuver on ultrasound, Rate of rise of diaphramatic amplitude during maximal inspiration on ultrasound, diaphragm thickness after maximal inspiration on ultrasound [cm], diaphragm thickness after maximal exspiration on ultrasound, diaphragm thickness after tidal breathing on ultrasound [cm], thickening ratio [n.u.], -> the above mentioned values will be obtained by means of diaphragm ultrasound, twitch transdiaphragmatic pressure after magnetic cortical stimulation of the phrenic nerves [cmH2O], twitch gastric pressure after thoracic magnetic stimulation of the (expiratory) abdominal muscles [cmH2O] phrenic nerve conduction time after cortical magnetic stimulation [ms], phrenic nerve conduction time after cervical magnetic stimulation [ms], Amplitude of compound diaphragm muscle action potential after cortical magentic stimulation [mA], Amplitude of compound diaphragm muscle action potential after cervical magnetic stimulation [mA], central motor conduction time [ms], transdiaphragmatic pressure after voluntary maneuvers [cmH2O], Releaxation-rate of Twitch transdiaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [msec], The above mentioned values will be obtained through intraosophageal and intragastral balloon catheters with pressure recordings in | — |
Countries
Germany
Contacts
Public ContactLars Henning Schmidt
Medizinische Klinik A Universitätsklinikum Münster
Outcome results
None listed