E66.99 overweight and obesity
Conditions
Interventions
Group 1: Time points and analyses
T0 (pre-operative): standardised medical history, bio-impedance analysis, blood samples, COMET measurement.
T1 (operation): biopsies
T2 (3 +/-1 months after surgery)
Sponsors
NWG Translational Septomics, Zentrum für Innovationskomepetenz (ZIK) Septomics, Universitätklinikum Jena
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.) Grad 3 obesity with BMI =40 kg/m2 and significant metabolic comorbidity, EOSS (Edmonton Obesity Staging System) stage = 2 with truncal obesity 2.) written informed consent
Exclusion criteria
Exclusion criteria: 1.) Contra-indications to bio-impedance and COMET analysis 2.) Pregnancy or breastfeeding period 3.) Participation in another interventional study 4.) Prior participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in relative fat mass 6 months after surgery compared with the pre-operative state. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.) Change in mitochondrial oxygen metabolism (mitoPO2, mitoVO2 and mitoDO2) 6 and 12 months after surgery compared with before the operation. 2.) Explorative analyses of the relationship between bio-impedance analysis parameters and mitoPO2 and mitoVO2 values 6 and 12 months after surgery compared with before the operation. 3.) Changes in body composition, especially visceral fat and muscle mass before the operation compared with 3, 6, 9 and 12 months after. 4.) Influence of bariatric surgery on laboratory parameters, specifically metabolome, lipidome, immune function and epigenetics. | — |
Countries
Germany
Contacts
Public ContactMarkus Engelmann
NWG Translational Septomics, Zentrum für Innovationskompetenz (ZKS) Septomics, Universitätsklinikum Jena
Outcome results
None listed