F60.3
Conditions
Interventions
Group 1: 30 mothers with BPD and their child (aged 18-36 month)
Procedure:
1. Diagnostics
2. Questionnaires
3. Observation of mother-child interaction followed by video-Analysis and hormon Analysis b
Sponsors
Klinik für Allgemeine Psychiatrie
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Females with BPD • mother of a child aged 18-36 month • Age: 18-50 years • diagnosis of BPD (= 5 DSM-IV criteria in International Personality Examination Interview (IPDE) section BPD) Healthy females • mother of a child aged 18-36 month • Age: 18-50 years • no current or lifetime mental disorder (M.I.N.I./IPDE) Children • Age: 18-36 month • living with mother
Exclusion criteria
Exclusion criteria: Females with BPS • Missing capacity to consent • ager 50 years • psychotropic medication (exception SSRIs und SSNRIs) • current or lifetime bipolar disorder or schizophrenia • current substance abuse • addiction in the last 2 years • brain trauma, Tumor, significant neurological or medical factors • pregancy • acute suicidality Healthy females • Missing capacity to consent • ager 50 years • psychotropic medication • current or lifetime bipolar disorder or schizophrenia • current substance abuse • addiction in the last 2 years • brain trauma, Tumor, significant neurological or medical factors • pregancy • acute suicidality Children • age 36 month • Mental or physical disabilities • Severe physical illness • Endangerment of child's welfare For fMRI • Psychotropic medication • left-handedness • contradictions for MRI (e.g implants)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavior observation 1A: behavioral indices according to the „Coding Interactive Behavior“ Systems (CIB) (Feldman, 1998) taken seperately from 3 paradigms (freeplay, puppet, toy removal). CIB includes 45 scales, which can be rated from 1-5. Frequency, Duration and latency can be analyzed. Additionally, „Positive and Negative Affect Schedule“ (Watson et al., 1988) will be used. 1B: Plasma oxytocin and cortisol before and after freeplay fMRI 2A: behavioral evaluation of mother's affect and arousal 2B: BOLD (blood oxygenation level dependent) Signal in reward system (Striatum, orbitofrontal cortex, cingulum, ventral pallidum, ventral tegmentum, substantia nigra), as well as in salience system (amygdala, insula, ACC) | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) hormonal Levels for estrogen, progesterone, testosterone (2) Questionnaires: General functioning (Global Assessment of Functioning; Saß et al., 2003; GAF), depression (Beck Depressionsinventar; Beck et al., 1996), empathy (Saarbrücker Persönlichkeits-Fragebogen zu Empathie; Paulus 2006), impulsivity (Barratt Impulsiveness Scale; Patton et al., 1995; BIS), borderline symptoms (Bohus et al., 2009; BSL), Emotion regulation (Gratz & Roemer, 2004; DERS), trauma (Childhood Trauma Questionnaire; Klinitzke et al., 2012), stress (Eltern-Belastungs-Inventar; Tröster 2010), attachment (Vulnerable Attachment Style Questionnaire; Bifulco et al., 2003), welfare of the child (Elternbelastungs-Screening zur Kindswohlgefährdung; Deegener et al., 2009; EBSK) and child behavior (Child Behavior Checklist; Achenbach 2000) (3) correlations between behavioral, neural, hormonal and questionnaire data (4) resting state activity, structural data | — |
Countries
Germany
Contacts
Public ContactIsabella Schneider
Klinik für Allgemeine Psychiatrie
Outcome results
None listed