J96 N17
Conditions
Interventions
Group 1: removal of carbon dioxide (CO2) and correction of acidosis via ADVOS treatment
Sponsors
Universitätsklinikum Schleswig-Holstein
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - invasive controlled ventilation at acute hypercapnic respiratory failure (PaCO2 > 45 mmHg) - tidal volume > 6ml/kg ideal weight or driving pressure difference (delta p) > 15 cmH2O required to reach a pH value > 7,30 - acute renal failure (KDIGO II or III) - clinical indication for continuous venovenous haemodialysis - consent to participate in the clinical trial
Exclusion criteria
Exclusion criteria: - severe acute hypoxemic respiratory failure (PaO2/FiO2 ratio 150 bpm or mean arterial pressure < 65 mmHg or cardiac output < 5 l/min despite adequate therapy) - elevated intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tidal volume (ml/kg ideal weight) to reach a ventilation with a pH value >7,30 and PaCO2 < 60 mmHg (measured 6 hours after the beginning of the ADVOS treatment) | — |
Secondary
| Measure | Time frame |
|---|---|
| - CO2 removal achieved with the ADVOS system (ml/min) - required alveolar ventilation per minute (l/min) - pressure difference between airway plateau pressure and PEEP (cmH2O) - change of power of ventilation (Joule/min) - partial pressure of oxygen (mmHg) - partial pressure of carbon dioxide (mmHg) - pH | — |
Countries
Germany
Contacts
Public ContactLars Hummitzsch
Klinik für Anästhesiologie und operative Intensivmedizin, Universtitätsklinikum Schleswig Holstein, Campus Kiel
Outcome results
None listed