Q61.2 N18
Conditions
Interventions
Group 1: Healthy Control Group 1 - Sequence optimization on 30 healthy subjects will be asked not to drink or eat 12 hours before MRI (T1-mapping, diffusion weighted imaging, diffusion tensor imaging,
Sponsors
Medizinische Universität Wien
Eligibility
Sex/Gender
All
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: healthy subjects: 18-39 years of age, Body Mass Index (BMI) between 17-30kg/m² and Cockcroft-Gault or MDRD estimate of creatinine clearance >70mL/min (based on medical reports not older than two years; otherwise blood will be drawn for a new evaluation). ADPKD subjects: 18-39 years of age, diagnosis ADPKD (type I or II) based on a positive family history and/or at least three kidney cysts (unilateral or bilateral), BMI between 17-30kg/m², Cockcroft-Gault or MDRD estimate of creatinine clearance >70mL/min (based on medical reports not older than two years; otherwise blood will be drawn), no albuminuria, and total cystic volume under 350mL and 450mL for women and men, respectively. Participants with a disputable ADPKD diagnosis or unmeasured kidney and cysts dimensions will be able to undergo an MRI evaluation, in order to prevent subjects to undergo an unnecessary renal function scintigraphy test.
Exclusion criteria
Exclusion criteria: healthy subjects: pregnancy, breast feeding, mean seated blood pressure above 145/95mmHg and seated heart rate above 100 beats per second, diabetes mellitus (fasting glucose >126mg/dl, treatment with insulin or oral hypoglycemics), known atrial fibrillation or atrioventricular block grade II or higher, history of myocardial infarction, unstable angina pectoris, evident congestive heart failure (New York Heart Association class III/IV), established renal impairment or chronic disease potentially affecting renal function, and intake of antihypertensive medication, nonsteroidal antiinflammatory drugs like acetylsalicylic acid or diuretics, implants, which are not safe for 3T. ADPKD subjects: pregnancy, breast feeding, mean seated blood pressure above 160/100mmHg and seated heart rate above 100 beats per minute, diabetes mellitus (fasting glucose >126mg/dl, treatment with insulin or oral hypoglycemics), known atrial fibrillation or atrioventricular block grade II or higher, history of myocardial infarction, unstable angina pectoris, evident congestive heart failure (New York Heart Association class III/IV), established moderate renal impairment (GFR category G3a or higher and albuminuria category A2 or higher) or other systemic diseases potentially affecting renal function, intake of nonsteroidal antiinflammatory drugs like acetylsalicylic acid or diuretics, and previous renal surgery or cyst drainage procedures, implants, which are not safe for 3T..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reproducibility and alteration of quantitative T1 relaxation time, apparent diffusion constant, fractional anisotropy, and Stiffness due to fluid intake (z.B. Wasser, Fruchtsäfte) on healthy and ADPKD subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| Alterations and Correlations during the course of the ADPKD. | — |
Countries
Austria
Contacts
Public ContactMarcos Wolf
Medizinische Univeristät WienZentrum für Medizinische Physik und Biomedizinische Technik
Outcome results
None listed