G05
Conditions
Interventions
Group 1: The first study arm are patients with suspected septic encephalitis: Liquor samples are taken via external ventricle drainage. Additionally blood cultures samples are taken.
The samples will
Sponsors
Westpfalz-Klinikum Kaiserslautern
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: • declaration of consent signed by participant of the clinical trial or the participant’s legal representative • age > 18 years • encephalitis: suspected inflammation of brain tissue that is accompanied by neurological dysfunction • lying or indicated CSF (Cerebrospinal fluid) drainage
Exclusion criteria
Exclusion criteria: • age < 18 years • refusal of participation • transfer from intensive care unit in the first 72h after beginning of clinical trial is very likely • palliative therapy • limitation of therapy possible • death of patient is already in the beginning of clinical trial predictable and seems unavoidable • patients, that have been included in the study and are retransferred to the intensive care unit, can’t be included a second time • pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Microbial detection from CSF-samples (Cerebral spinal fluid) by use of NGS (Next-Generation Sequencing) - Comparison with blood culture - CSF-samples and blood-sampled are drawn at a particular time | — |
Secondary
| Measure | Time frame |
|---|---|
| - Evaluation of results using SIQ (Sepsis Indicating Quantifier) Score - aim of clinical trial: new approaches for future diagnostics of encephalitis for patients under intensive care | — |
Countries
Germany
Contacts
Public ContactStefan Hofer
Westpfalz-Klinikum Kaiserslautern
Outcome results
None listed