E66
Conditions
Interventions
Group 1: Liver and adipose biopsies during bariatric/metabolic surgery
Sponsors
Universitätsklinikum FreiburgKlinik für Allgemein- und Viszeralchirurgie
Eligibility
Sex/Gender
Female
Age
18 Years to 49 Years
Inclusion criteria
Inclusion criteria: 1) Obesity WHO III (BMI>40 kg/m2) 2) Obesity WHO II (BMI 35-40 kg/m2) + obesity related diseases (diabetes, hypertension, hyperlipidemia, osteoarthrosis, obstructive sleep apnea, obesity hypoventilation syndrome, nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH), pseudotumor cerebri, gastroesophageal reflux disease, asthma, venous stasis disease, severe urinary incontinence, debilitating arthritis, impaired quality of life, disqualification for other surgeries as a result of obesity (i.e., surgeries for osteoarthritic disease, ventral hernias, or stress incontinence) Female, caucasian, >=18 years <50 years
Exclusion criteria
Exclusion criteria: Patients with high perioperative risk, previous bariatric surgery, carcinoma within the last 5 years, severe psychiatric disease, drug or alcohol abuse,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study has no comparative outcome. The focus lies in its bioinformatic approach which relies on dimensional reduction and clustering of RNAseq-data and quantifiable clinical parameters to define patient clusters. In this way the entire spectrum currently globally termed as obesity will be more precisely defined. | — |
Secondary
| Measure | Time frame |
|---|---|
| see primary outcome | — |
Countries
Germany
Contacts
Public ContactOlivia Sick
Universitätsklinikum Freiburg Abteilung Allgemien- und Viszeralchirurgie
Outcome results
None listed