I25.1 K05.3
Conditions
Interventions
Group 1: Observational study, cohort study
Cardiovascular Outcome 30 days, 1 and 3 years after aortic coronary artery bypass surgery (ACB-OP) depending on periodontal disease, oral microbiome and ora
Sponsors
Martin-Luther-universität Halle-WittenbergUniversitätspoliklinik für Zhanerhaltungskunde und Parodontologie
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: unrelated Caucasians, > 50% stenosis of a major coronary artery; at least 4 own teeth, need for ACB surgery
Exclusion criteria
Exclusion criteria: lack of consent to participate in the study, diseases or dysfunctions that exclude participation in a clinical trial, participation in a clinical trial 30 days prior to initiation of this study, systematic periodontitis or antibiotic treatment 6 or 3 months prior to enrollment, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of new cardiovascular events (combined endpoint: myocardial infarction, revascularization, stroke, transient ischemic attack, cardiac death, and death from stroke) one year after ACB surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome 30 days after ACB surgery MACCE (major adverse cardiac and cerebrovascular events) criteria and 30-day lethality (combined endpoint). Incidence of new cardiovascular events (combined endpoint: myocardial infarction, re-revascularization, stroke, transient ischemic attack, cardiac death, and death from stroke) three years after ACB surgery. | — |
Countries
Germany
Contacts
Public ContactStefan Reichert
Martin-Luther-Universität Halle-WittenbergDepartment für ZMK, Universitätspoliklinik für Zahnerhaltungskunde und Parodontologie
Outcome results
None listed