healthy aging
Conditions
Interventions
Group 1: Data collection of 48 male subjects divided into 4 groups:
1. 12 young (20-35 years), athletes
2. 12 young (20-35 y.), untrained
3. 12 older (60-75 years), athletes
4. 12 elderly (60-75 year
Sponsors
DLR - Institut für Luft- und RaumfahrtInstitut für Luft- und Raumfahrtmedizin
Eligibility
Sex/Gender
Male
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: • Regular running training (=4 hours per week) and participation in running competitions (athlete groups) • Little or no physical activity, as defined by exercise-related energy expenditure of = 2 metabolic units per week (sedentary groups) • Age between 20 and 35 (young groups) • Age between 60 and 75 (old groups) • Male • Body mass index = 25 kg/m² • Ability to consent • Agreement and signed informed consent before the study
Exclusion criteria
Exclusion criteria: • Injuries or disorders that interfere with calf muscle contractions or with vertical jump testing • Contraindications against magnetic resonance scanning • Contraindications against muscle biopsy • Diabetes • Any condition classed as unsuitable by the executive medical director
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Muscle’s endomysium content (soleus biopsy, histology) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Muscle’s collagen content (soleus biopsy, Western blot) - Muscle’s advanced glycation end products (soleus biopsy, ELISA) - Muscle’s collagen cross-linking (soleus biopsy, ELISA) - Muscle’s perimysium content (ultrasound) - Muscle fascicle dynamics, defined as change in pennation angle between 10% and 90% of maximum voluntary contraction (B-mode ultrasound & dynamometry) - Muscle’s elastic modulus (shear wave sonography) at rest and during graded contraction up to maximum | — |
Countries
Germany
Contacts
Public ContactJörn Rittweger
Institut für Luft- und Raumfahrtmedizin, DLR
Outcome results
None listed