M62.5 M62.9
Conditions
Interventions
Group 1: Conventional resistance training of the lower extremity
Group 2: Modified resistance training including stimuli to target intramuscular connective tissue
Group 3: Control group
Sponsors
Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik
Eligibility
Sex/Gender
All
Age
65 Years to 70 Years
Inclusion criteria
Inclusion criteria: Physical readiness to participate in planned resistance training
Exclusion criteria
Exclusion criteria: Coronary heart disease; Severe pulmonary (> 55 mmHg) or systemic arterial hypertension (> 160/95 mmHg); Acute disease or infection; Musculoskeletal disorders (e.g., severe osteoarthritis of the knee); Blood clotting disorders or taking of anticoagulant medicines or platelet aggregation inhibitors; Malnutrition (Mini Nutritional Assessment); Any contraindication for MRI; Hormone replacement therapy; Regular strength training within 6 months prior to inclusion; Moderate to severe peripheral artery disease; Severe varicosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Isometric and isokinetic muscle strength of knee extensor and ankle plantarflexor muscles | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional performance measures (timed sit-to-stand, handgrip strength, 6-min walk test); Muscle volumes, architecture and echogenicity; Gene expression and network proteins of intramuscular connective tissue (muscle biopsies); Muscle fiber types; Neural activation capacity | — |
Countries
Austria
Contacts
Public ContactRobert Csapo
Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik
Outcome results
None listed