Influence of the nitrinergic system on behavioral phenotypes and neuronal activity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00015735

Enrollment

167

Registered

2018-10-30

Start date

2019-02-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F20

Interventions

Group 1: schizophrenic patients: At one point of time, the 64-channel EEG will be recorded during the performance of 2 different working memory paradigms. Moreover, the EEG and the EMG (Startle) activ

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Healthy controls: Inclusion criteria are majority age and ability to consent. Schizophrenic patients: Inclusion criteria are majority age, ability to consent and the presence of a schizophrenia diagnosis.

Exclusion criteria

Exclusion criteria: Exclusion criteria for healthy controls are the presence of a psychiatric disorder or the presence of a psychiatric disorder in first-degree family members. For patients there are no exclusion criteria.

Design outcomes

Primary

Measure	Time frame
Comparison of schizophrenic patients and healthy controls (with NOS1- und NOS1AP-risk gene variants for schizophrenia). Primary outcome variables: event-related potentials during working memory tasks and prepulse inhibition (EMG of the M. orbicularis oculi) of the acoustically evoked startle response	—

Countries

Germany

Contacts

Public ContactMichael Plichta

Klinik für Psychiatrie, Psychosomatik und PsychotherapieUniversitätsklinikum Frankfurt

michael.plichta@kgu.de0049-69-6301-5897

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026