Volume therapy controlled by pulse pressure variation in major abdominal surgery

Volume therapy controlled by pulse pressure variation in major abdominal surgery - Peak-to-Peak Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00015710

Enrollment

720

Registered

2019-01-22

Start date

2012-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major abdominal surgery

Interventions

Group 1: basal volume therapy 4 ml/kg crystalloid fluid plus 500 ml fluid bolus when PPV > 10% Group 2: basal volume therapy 4 ml/kg crystalloid fluid plus 500 ml fluid bolus when PPV > 30%

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: major visceral surgery > 3 h operation time

Exclusion criteria

Exclusion criteria: rejected agreement, age 85 y, ASA physical status IV and V, atrial fibrillation

Design outcomes

Primary

Measure	Time frame
length of hospital stay	—

Secondary

Measure	Time frame
mortality, surgical complications, length of ICU stay, degradation of glycocalyx layer	—

Countries

Germany

Contacts

Public ContactThomas Weber

Klinik für Anästhesiologie und Operative Intensivmedizin, Katholisches Klinikum Bochum

sekr-anae@klinikum-bochum.de+49 (0)234 509 3211

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026