Analysis of extracellular vesicles and circulating microRNAs in remote ischemic preconditioning of coronary artery disease patients dependent on anesthetic regime

Analysis of extracellular vesicles and circulating microRNAs in remote ischemic preconditioning of coronary artery disease patients dependent on anesthetic regime - ExoRIP

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00015682

Enrollment

100

Registered

2018-12-20

Start date

2019-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.1

Interventions

Group 1: Placebo: given the standard therapy, so no preconditioning, applying the blood pressure cuff but no pumping up the cuff Anesthetic: isoflurane Group 2: Placebo: given the standard therapy, so

Eligibility

Sex/Gender

All

Age

45 Years to 85 Years

Inclusion criteria

Inclusion criteria: Coronary heart disease • CABG (Coronary artery bypass graft) surgery with cardiopulmonary bypass • ages 45 to 85 years • Antegrade Bretschneider cardioplegia • Mild hypothermia (32C °) • Preoperative standard medication (statins, beta-blockers, aspirin) • Standard anesthesia (isoflurane, sufentanil) • Intraoperative standard protocol (full heparinization with ACT> 400s, aprotinin, protamine) • Postoperative standard protocol (500mg aspirin after 2 hours, Low-dose heparinization after 4h)

Exclusion criteria

Exclusion criteria: Condition after acute myocardial infarction • combined valvular • Emergency operation • catecholamine • Unstable angina • IABP mounting • pre- / intraoperative use of phosphodiesterase inhibitors • reoperation • COPD GOLD III and IV • renal insufficiency with creatinine> 1.5 mg / dl • Dual antithrombotic therapy (clopidogrel + aspirin) Repeated cardiopulmonary bypass • Repeated cross clamping of the aorta • Intraoperative complications (bypass "low-flow" / -lock, frustrane valve reconstruction, Klappenausriss, aortic dissection, pump failure, implantation of cardiac assist systems) • aortic cross clamping> 150 min • Moderate / deep hypothermia (<32C °) • Antithrombotic therapy (intraoperatively clopidogrel u. / O. Aspirin) • Retrograde cardioplegia delivery

Design outcomes

Primary

Measure	Time frame
Change of exosomal signature one hour after intervention	—

Secondary

Measure	Time frame
maximal postoperative troponin I increase within 7 days after coronary artery bypass surgery postoperatively	—

Countries

Germany

Contacts

Public ContactPeter Zahn

Ruhr-Universität BochumBG Universitätsklinikum Bergmannsheil GmbHKlinik für Anästhesiologie,Intensiv-, Palliativ- und Schmerzmedizin

zahn@ains-bergmannsheil.de+49 234 302-3529

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026