F32 F33 F31.3 F31.4 F43.2
Conditions
Interventions
Group 1: Depressed patients with previous suicidal behavior (suicide ideas, realized or interrupted suicide attempts) within the last six months.
Participants of all three groups will be examined in
Emotional Stroop-Task (EST
main parameters: reaction times and accuracy under emotional conflicts)
and the Stop-Signal-Response-Task (SSRT
main parameters: impulsivity and reaction inhibition).
Additionally, the electrodermal activity (EDA) will be measured in a non-invasive procedure, in order to assess the emotional activity.
Hereaf
Sponsors
Universitätsklinikum der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria: - Subject is 18 to 60 years of age on the day of signing informed consent. - Subject agrees to participate by providing written informed consent - Subject is able to obtain full insight into the objectives of the clinical trial and is fully contractually capable as assessed by an independent psychiatrist. - For patients: voluntary treatment in the Department for Psychiatry, Psychotherapy and Psychosomatics. Special inclusion criteria: Group 1 - Suicidal behavior (suicide ideas, realized or interrupted suicide attempts) within the last 6 months - Subject meets ICD-10 criteria for single depressive episode (F32.x), bipolar depression (F31.x), recurrent depression (F33.x) or adjustment disorder with depressive reaction (F43.2). - Absence of acute suicidality and stabile psychopathological state. - Persistence of depressive symptoms (BDI = 14). Group 2 - Lifetime absence of suicidal behavior (suicide ideas, realized or interrupted suicide attempts) - Subject meets ICD-10 criteria for single depressive episode (F32.x), bipolar depression (F31.x), recurrent depression (F33.x) or adjustment disorder with depressive reaction (F43.2). - Absence of acute suicidality and stabile psychopathological state. - Persistence of depressive symptoms (BDI = 14). Group 3 - Healthy volunteers without a history of mental diseases or suicidality
Exclusion criteria
Exclusion criteria: - Any comorbidity including following diagnostic categories: Organic, including symptomatic, mental disorders (F00-F09), Schizophrenia, schizotypal and delusional disorders (F20-F29), Mental retardation (F70-F79), Disorders of psychological development (F80-89). - Subject has an unstable, severe medical disorder. - Subject is hospitalized or treated coercively by order of the responsible local authorities. - Subject (in the investigator's and - if necessary - an independent psychiatrist’s judgment) poses a serious suicidal or homicidal risk at the screening visit - Subject has a clinically significant abnormality in the neurological assessments at screen or base - subject is in a dependent position toward the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The current study aims to test previously suicidal, depressed patients compared to depressed patients without suicidality and healthy controls with regard to following primary outcome parameters: Decision-making task (DOSE): loss aversion und risk aversion Emotional stroop task (EST): Interference effect Stop-Signal-Response-Task (SSRT): Inhibition effect Childhood Trauma Questionnaire (CTQ): summarized score and subscores for physical, mental and sexual traumatic experience | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters will be assessed using the following questionnaires and examinations: -Becks Depressions Inventory-II (BDI-II; Self rating) und Hamilton Depression Scale (HAMD) (external rating) -Suicide Severity Rating Scale (C-SSRS), German Capability for Suicide Questionnaire (GCSQ), Interpersonal Needs Questionnaire (INQ) (assessment of suicidality) -Beck Hopelessness Scale (assessment of hopelessness) -Temperament and Character Inventory (TCI) (assessment of personality attributes) - Trail Making Task – TMT(A) und TMT(B) (cognitive flexibility) - Barratt Impulsiveness Scale (BIS-11) (Impulsiveness) -Cognitive Fusion Questionnaire (CFQ-D) und Metacognitions Questionnaire (MCQ) (ability of cognitive fusion) -Laboratory parameters: Testosterone, Estrogen, Progesterone, Brain-derived neurotrophic factor (BDNF), Cortisol. - Elektrodermal Activity (EDA) | — |
Countries
Germany
Contacts
Public ContactTanja Veselinovic
Klinik für Psychiatrie, Psychotherapie und PsychosomatikUniklinik RWTH Aachen
Outcome results
None listed