A41
Conditions
Interventions
Group 1: - Clinical evaluation of the collagen activated platelet function on day 0, 1, 2, 3, 4, 5, 8, 11, 14 after a diagnosed sepsis
- Clinical evaluation of the ADP (adenosine diphosphate), thrombo
Sponsors
Knappschaftskrankenhaus Bochum-Langendreer
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosed Sepsis due to the Sepsis III Definition And 2. At least two fullfilled SIRS (Systemic inflammatory response syndrome) criteria
Exclusion criteria
Exclusion criteria: 1. Antiplatelet therapy (ASS, ADP-receptor-antagonists and GPIIb/IIIa antagonists) and/or NSAR (non-steroidal anti-inflammatories) in the last four weeks 2. Age < 18 years 3. Congenital or acquired thrombocytopathies 4. Status after splenectomy 5. Pregnancy 6. Immunosuppressive therapy (Chemotherapy, transplant patients) 7. Diagnosed heparin induced thrombocytopenia (HIT 1 or 2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical evaluation of the collagen activated platelet function on day 0, 1, 2, 3, 4, 5, 8, 11, 14 after a diagnosed sepsis | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical evaluation of the ADP (adenosine diphosphate), thromboxane, and glycoprotein activated platelet function on day 0, 1, 2, 3, 4, 5, 8, 11, 14 after a diagnosed sepsis 2. Determining the predictive value, as well as the specificity and the sensitivity of collagen as a platelet activating substance 3. Compare the acquired date with other laboratory values for sepsis (PCT, CRP, leukocytes) 4. Analyse the correlation between the above mentioned parameters and further microbiological examination (blood cultures, tracheal secretion, urine) in the course of detecting the root of an infection | — |
Countries
Germany
Contacts
Public ContactTim Rahmel
Universitätsklinikum Knappschaftskrankenhaus Bochum
Outcome results
None listed