Multimodal approach in long term longitudinal in-vivo monitoring the clinical outcomes of graft maturation of injected matrix-assisted autologous chondrocyte transplantation in individual patients – clinical, morphological MRI and biochemical quantitative T2-mapping, T1rho and diffusion-weighted-imaging.

Multimodal approach in long term longitudinal in-vivo monitoring the clinical outcomes of graft maturation of injected matrix-assisted autologous chondrocyte transplantation in individual patients – clinical, morphological MRI and biochemical quantitative T2-mapping, T1rho and diffusion-weighted-imaging. - ACTIVE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00015471

Enrollment

Registered

2019-04-16

Start date

2019-06-06

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unspecified ligament or unspecified meniscus M22.4

Interventions

Group 1: Patients receive clinical-orthopedic as well as non contrast MRI-examinations (3 Tesla, Philips Ingenia or Siemens Magnetom Skyra) 3, 6, 12, 24 and 36 months after ACTinject treatment.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: minimum age 18 years, maximum age 60 years. Isolated cartilage defect of at least 2 cm² size. ACTinject treatment of the knee at least 3 month previously. Signed informed consent form.

Exclusion criteria

Exclusion criteria: More then 2 cartilage defects. (Osteo-)arthritis. Instability of the knee joint. Incomplete follow-up data. General contraindications for MRI.

Design outcomes

Primary

Measure	Time frame
Aim of this study is the explorative comparison of patients after ACTinject treatment for a duration of 36 months concerning clinical as well as MRI-parameters.	—

Secondary

Measure	Time frame
Temporal course of MRI-parameters in line with graft maturation. Correlation between clinical Parameters an MRI-parameters during different timepoints (3, 6, 12, 24 and 36 months).	—

Countries

Germany

Contacts

Public ContactChristel Besseler

Klinik und Poliklinik für Radiologie Klinikum der Universität München Campus Großhadern

christel.besseler@med.uni-muenchen.de(089) 4400-73647

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026