The influence of the adjunctive use of a probiotic losenge during supportive periodontal therapy

The influence of the adjunctive use of a probiotic losenge during supportive periodontal therapy - probiotic and SPT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00015318

Enrollment

Registered

2018-08-27

Start date

2017-03-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.3

Interventions

Group 1: Verum- probiotic losenge (Prodentis) twice daily for six months Group 2: placebo probiotic losenge (Prodentis) twice daily for six months

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: after active periodontal therapy minimum 16 natural teeth 2 – 8 sites with probing depth = 5 mm or 4 mm + BOP positive, not an adjacent teeth

Exclusion criteria

Exclusion criteria: age 5 cigarettes/day special nutrition habits (e.g. vegetarian or functional food/probiotics)

Design outcomes

Primary

Measure	Time frame
Probing depth in mm and bleeding on probing in % using a periodontal probe after six months.	—

Secondary

Measure	Time frame
attachment level in mm measured using a periodontal probe, after 3 and 6 months IL-1beta and MMP-8 in the gingival crevicular fluid after 3 and 6 months via ELISA-technique bacteria in the subgingival biofilm via PCR-technique after 3 and 6 months	—

Countries

Germany

Contacts

Public ContactHolger Jentsch

Funktionsbereich Parodontologie der Poliklinik für Zahnerhaltung und Parodontologie am Universitätsklinikum Leipzig AöR

jenh@medizin.uni-leipzig.de0341-9721208

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026