Alcohol induced hangover
Conditions
Interventions
Group 1: On study day one, study group 1 consumes beer up to a breath alcohol concentration (BrAC) of =0.05% and subsequently wine to a BrAC of 0.11%. On study day two (crossover), the wine and beer c
Sponsors
Witten/Herdecke University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male and female participants, Age: 18 to 60 years, Provided written informed consent (see attachment: consent form), Positive matched-triplet result, Positive history of beer and wine consumption
Exclusion criteria
Exclusion criteria: o Age: < 18 years o Limited legal competence/ability to make legal judgement o Chronic alcohol abuse or drug abuse o Aversion to beer or wine (or both) o Complete alcohol abstinence or intolerance o Diseases/conditions that - influence the metabolism of alcohol - may affect the trial outcome as well as - constitute a contraindication for alcohol consumption ? Alcoholic liver disease ? Viral hepatitis ? Hepatocellular carcinoma ? Chronic pain ? Diabetes mellitus type 2 ? Epilepsy ? Wernicke encephalopathy, thiamine deficiency ? Korsakov syndrome ? Gastritis, bariatric surgery ? Immunosuppression ? Recent history of infection (i.e. respirator, etc.) o Pregnancy of breastfeeding o Eastern Asian ethnicity - due to prevalence of congenital intolerance to alcohol o Use of medications known to interact with alcohol - via cytochrome 2E1 ? Paracetamol, Barbiturate, Isoniazid, ? Cyclophosphamide, Halothane, ? Methadone, Phenylbutazone, Propranolol ? Rifampicin, Warfarin, Tolbutamide ? Traquilizer, Vitamin A - via ADH ? Cimetidine, Ranitidine, Chlorpromazine ? Chloral hydrate - via ALDH ? Sulphonylurea, Sulfonamide, ? Metronidazole, Griseofulvin, Tolazoline ? Procarbazine, antimalarial agents ? Chloramphenicol - as well as ? Antidiabetics, Antibiotics, Opioids, Nitrates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the reported hangover severity on the day following each intervention. Hangover intensity is scored by acute hangover scale (AHS, Rohsenow et al. 2007) – an eight-item compound score (including thirst, fatigue, headache, dizziness, nausea, stomach ache, tachycardia and loss of appetite). Each item is rated between 0 and 7 by the study subject on the day following the intervention, once BrAC has returned to zero. A score of 56 corresponds to the worst imaginable hangover, 0 represents the absence of hangover symptoms. Study groups 1 and 2 and the control group will be compared regarding AHS values on the day following each intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints are factors associated with hangover intensity (e.g. demographics, laboratory parameters, self-assessment of perceived drunkenness, etc.). | — |
Countries
Germany
Contacts
Public ContactKai Hensel
Universität Witten/Herdecke
Outcome results
None listed