K05.3
Conditions
Interventions
Group 1: subgingival instrumentation, with Placebo-probiotic gel (1x at SRP, after 1 week and after 3 months) and placebo-lozenge (1 lozenge per day for 6 months)
Group 2: subgingival instrumentation,
Sponsors
Poliklinik für Parodontologie
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: • no generalized moderate chronic periodontitis • minimum 16 teeth • minimum 2 pockets with 5-7 mm probing depth and BOP +
Exclusion criteria
Exclusion criteria: -periodontal therapy within the last year -intake of antibiotics within the last 3 months -gravidity and lactation -diseases with relation to periodontitis -allergies on components of the probiotic gel/ photosensitizer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| probing depth and attachment Level, in mm using a periodontal probe at baseline and after 3 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| bleeding on probing in % with periodontal probe, periodontopathogenic bacteria in the subgingival biofilm via PCR-technique at baseline and after 3 and 6 months Il-1, Il-10 and MMP-8 via ELISA-technique in the gingival crevicular fluid at baseline and after 3 and 6 months | — |
Countries
Germany, Romania
Contacts
Public ContactHolger Jentsch
Funktionsbereich Parodontologie der Poliklinik für Zahnerhaltung und Parodontologie
Outcome results
None listed