DSM-IV 309.81 Posttraumatic Stress Disorder, DSM-IV 296.2x/296.3x Major Depressive Disorder, DSM-5 300.82 Somatic Symptom Disorder F43.1 F32.0 F32.1 F32.2 F33.0 F33.1 F33.2
Conditions
Interventions
Group 1: Patients with posttraumatic stress disorder (n = 36), somatic symptom disorder (n = 36) and depression (n = 36), as well as healthy controls with adverse childhood experiences (n = 36) and he
Sponsors
Klinik für Allgemeine Psychiatrie, Zentrum für Psychosoziale Medizin der Universität Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: for patients: - posttraumatic stress disorder, somatic symptom disorder or major depression as first lifetime and still current diagnosis for healthy controls: - no current and no past psychiatric Axis-I disorder
Exclusion criteria
Exclusion criteria: for patients - unable to consent - pregnancy - psychotropic medication with the exception of regular medication with antidepressants, antipsychotics for sleep-induction, and pregabalin - current/past bipolar I disorder or schizophrenia - current/ past epilepsy - known brain traumata, brain tumor or other significant neurological/ medical factors - substance addiction during the last two years prior to study admission - current substance abuse - left handedness for all healthy controls - unable to consent - pregnancy - psychotropic medication - current/ past epilepsy - known brain traumata, brain tumor or other significant neurological/ medical factors - substance addiction during the last two years prior to study admission - current substance abuse - left handedness Further exclusion criterion for healthy controls without adverse childhood experiences - above-threshold scores of adverse childhood experiences as established by a validated instrument measuring adverse childhood experiences
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interaction effect (intensity of adverse childhood experiences x functional domain): Patients and healthy controls with high intensity of adverse childhood experiences show a threat hypersensitivity, a diminished reward sensitivity and a reduced theory of mind capacity compared to patients and healthy controls with low intensity of adverse childhood experiences. Measurements will be taken on one day. | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiac interoception capacity, measured with the subjectively counted heart beats and the electrocardiographic activity. Measurements will be taken on the same day as the primary outcomes are measured. | — |
Countries
Germany
Contacts
Public ContactKatja Seitz
Klinik für Allgemeine Psychiatrie, Zentrum für Psychosoziale Medizin der Universität Heidelberg
Outcome results
None listed