Chronic pruritus in atopic dermatitis, brachioradial pruritus and uremic pruritus L30.8 L29.8 L29.9
Conditions
Interventions
Group 1: In this project, we aim to investigate the influence of skin alterations by chronic scratching (lichenified vs. non-lichenified skin) on the peripheral and central level. We will perform fMRI
Sponsors
Uniklinik MünsterInstitut für klinische Radiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Chronic pruritus in atopic dermatitis, brachioradial pruritus, or uremic pruritus - Healthy age- and gender-matched controls - Age: = 18 years - Skin Type I-IV (after Fitzpatrick)
Exclusion criteria
Exclusion criteria: Taking antipruritic medication Infection at the examination area Pregnancy or lactation Metal implants in the body, claustrophobia, wearing ferromagnetic and non-removable jewelery, tattoos or cosmetics, consent, no stroke or severe depression / other mental illnesses or acute, no known strong calcification of the cerebral vessels and if previous imaging findings are present: no abnormal brain structure changes and / or severe volume reduction (atrophy) of the brain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRT: activation profiles, network maps, volumetric data, and white matter microstructure of the brain in lichenified vs. non-lichenified - vs. healthy skin in patients with pruritus of different entity compared and compared to healthy controls - depending on clinical parameters (in patients) QST (quantitative sensory testing): individual QST parameters - in lichenified vs. non-lichenified vs. healthy skin in patients with pruritus of different entity compared and compared to healthy controls, as well as dependent on clinical symptoms CMP / CIM (conditioned pain/itch modulation): endogenous inhibition (pruritus / pain) in patients with pruritus of different entity compared and compared to healthy controls as well as clinical symptoms. The measurements will be performed on Tuesdays and Wednesdays, lasting one hour each. | — |
Secondary
| Measure | Time frame |
|---|---|
| Structure data of the brain Difference between cowhage and NaCl control correlation of MRI results (a) with nerve fiber density (data collected in project 2) (b) with clinical pruritus parameters (c) with QST results | — |
Countries
Germany
Contacts
Public ContactSonja Ständer
Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikum Münster
Outcome results
None listed