F32.1 F34
Conditions
Interventions
Group 1: Intervention Group: graded exercise test on a stationary bicycle
Individuals aged 18-60 with partially remitted depression and subjective cognitive deficits
Procedure: 1. Standardized diagnos
Sponsors
Universitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1)Outpatients with a current or past-time diagnosis of major depressive disorder (2)Age between 18 and 60 years (3)IQ>80 according to the Mehrfachwahl-Wortschatztest B (MWT-B) (4)Clinically stable patients who are able to provide informed consent (5)Subjective Cognitive Complaints
Exclusion criteria
Exclusion criteria: (1)Psychiatric co-morbidities as identified by mini international neuropsychiatric interview: current substance (alcohol or drug) abuse and dependence, current or lifetime psychotic disorder and mania, current anorexia, bulimia, PTSD, and panic disorder (2)Reported current or chronic neurological disorders (3)Patients with Hamilton Rating Scale for Depression (HAMD-21) scores = 20 will be excluded to avoid confounding with severe depressive symptoms. (4)Physical fitness: Patients with somatic conditions presenting a risk to the graded exercise test will be excluded, e.g., unstable angina pectoris, symptomatic arrhythmia, symptomatic aortic stenosis, heart failure, acute pulmonary embolism, acute myocarditis, acute pericarditis, acute aortic dissection, high grade coronary artery disease, uncontrolled hypertension (RR>200/110mmHg), hypertrophic cardiomyopathy, endocarditis, symptomatic congenital and acquired heart defects. Furthermore, patients who cannot sufficiently participate in the graded exercise test due to health issues, e.g. COPD, severe asthma, current severe allergies, severe obesity (bodyweight >180kg, weight limit of the stationary bicycle), orthopedic disabilities will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BDNF serum concentration in ng/ml, assessed on date of test, before and after physical activity | — |
Secondary
| Measure | Time frame |
|---|---|
| parameters of cognitive functioning assessed via the test battery COGBAT, assessed on date of test at the end of the procedure | — |
Countries
Germany
Contacts
Public ContactDaniela Roesch-Ely
Universitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für Allgemeine Psychiatrie, Arbeitsgruppe Neurokognition
Outcome results
None listed