Hemodynamic and oxidative stress response to anesthesia and surgery during elective caesarean section
Conditions
Interventions
Group 1: Utiva (remifentanil), 1 µg/kg iv bolus followed by infusion 0.15 µg/kg/min
Group 2: Utiva (remifentanil), 1 µg/kg iv bolus before the induction to anesthesia
Group 3: patients who are not giv
Sponsors
Clinic of Gynaecology and Obstetrics University Clinical Center Nis
Eligibility
Sex/Gender
Female
Age
19 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients ASA I and II status, scheduled for elective caesarean section in general anesthesia who have given written informed consent. All patients refuse or have absolute/relative medical contraindications to regional anesthesia.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: known cardiac, respiratory, neurologic, renal, endocrine, psychiatric disorders, history of drug or alcohol abuse, morbid obesity, preeclampsia, predicted difficult airway management, active labor, known fetal congenital abnormalities or signs of fetal compromise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main goal is to compare the changes of maternal blood pressure, heart rate values measured after endotracheal intubation, skin incision, peritoneal incision and delivery during caesarean cestion between groups that were under different remifentanil dosing regimens and to investigate the effect of those regimens on oxidative stress. | — |
Secondary
| Measure | Time frame |
|---|---|
| We also compare neonatal outcome between groups (Apgar scores at 1st and 5th minute, HR, oxygen saturation, the need for resuscitative measures and umbilical venous and arterial blood gas values). | — |
Countries
Serbia
Contacts
Public ContactMarija Kutlesic
Clinic of Gynaecology and Obstetrics University Clinical Centre Nis
Outcome results
None listed