The molecular skeletal muscle adapation of healthy male subjects will be investigated. Basis for this approach is the frequent collection of skeletal muscle biopsies.
Conditions
Interventions
Group 1: solely a single group of subjects will be trained over several weeks. During this time several muscle biopsies will be collected and inverstigated
Sponsors
Deutsche Sporthochschule Köln / Abteilung für molekulare und zelluläre Sportmedizin
Eligibility
Sex/Gender
Male
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: healthy men between 20 and 35 years without acute health problems or orthopedic injuries in the knee area / willing to contribute in the study and fit for exercise
Exclusion criteria
Exclusion criteria: unfit for exercise / general unhealthy or acute health problems / orthopedic injuries knee area
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the molecular adaptation of mechanoprotective systems in human skeletal muscle in response via western blotting, phosphoproteomics, immunohistochemistry and electron microscopy. Primary endpoints will be determined when subjects have underwent the entire study section. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood samples, force development of skeletal muscle and myofiber hypertrophy / Questionnaires to estimate subjective muscular loading and muscle pain. Secondary endpoints will be determined to defined time points throughout the study. | — |
Countries
Germany
Contacts
Public ContactSebastian Gehlert
Deutsche Sporthochschule Köln / Institut für Kreislaufforschung und Sportmedizin / Abteilung für molekulare und zelluläre Sportmedizin
Outcome results
None listed