G43
Conditions
Interventions
Group 1: Migraine patients are examined once regarding offset analgesia and quantitative sensory testing at the forehead and forearm.
Group 2: Healthy controls are examined once regarding offset analg
Sponsors
Universität zu Lübeck
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients: Adult patients with episodic migraine, defined as 2 to 15 headache days per month, are diagnosed by a headache experienced neurologist according to the IHS classification version III (IHS, 2018). All patients must have been headache free for at least 48 hours on the day of the examination. After 48 hours, patients will also be contacted to ensure that they have been in the interictal migraine phase. Recruitment takes place in the headache outpatient department of the University Hospital Hamburg-Eppendorf. Control subjects: Healthy persons who correspond to the patient group in terms of age and sex. Control subjects must not suffer from headache more than once a month and must not meet the criteria for primary headache disorder, except for rare episodic tension headache.
Exclusion criteria
Exclusion criteria: - Pregnancy, breast-feeding - Pain medications on more than 10 days per month to rule out medication-overuse headache - internistic, psychiatric or neurological pre-existing disorders - acute pain including toothache and muscles soreness - Further chronic pain disorder (back pain, neck pain, etc.) for at least 6 weeks, occurs on >4 days per week and reaches an intensity > 20/100 on the visual analogue scale (VAS). - Skin disease in the reference area of the N.trigeminus (1st branch) or in the area of the forearm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is offset analgesia, i.e. the subjective reduction of pain intensity after a slight temperature reduction of 1°C in migraine patients in the area of the trigeminal nerve and forearm. The measurement is performed once in the interictal migraine phase. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the correlation of offset analgesia with elements of quantitative sensory testing and with migraine-induced impairment as measured by the Migraine Disability Score (MIDAS). The measurement is performed once in the interictal migraine phase at the same time as the primary endpoint. | — |
Countries
Germany
Contacts
Public ContactKerstin Lüdtke
Universität zu Lübeck
Outcome results
None listed