C50
Conditions
Interventions
Group 1: Provision of surgical material to establish four distinct 3D cell culture models from tissue of carcinomas of the breast. Subsequently take place a molecular characterization of exom, RNA seq
Sponsors
OncoRay - National Center for Radiation Research in Oncology and Dept. of Radiation OncologyUniversitätsklinikum and Medizinische Fakultät Carl Gustav Carus
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Pretherapeutic; - Operable status; - Mamma-Ca: All patients who have one receive adjuvant radio (chemo) therapy; - Fresh tissue surgical material available for scientific study; - surgical report and written histology findings from the Görlitz Hospital available; - general condition WHO 0-2; - Age = 18 years
Exclusion criteria
Exclusion criteria: - Systemic medical therapy, radiotherapy or chemoradiotherapy; - Lack of insight or lack of cooperation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3D cell culture establishment and molecular characterization of 3D cell culture systems with and without in vitro therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Survey of clinical pathological characteristics and course of therapy / follow-up with subsequent linking of the molecular data from the 3D cell cultures with the clinical course. | — |
Countries
Germany
Contacts
Public ContactDoreen Christoph
Städtisches Klinikum Görlitz Sekretariat Klinik für Gynäkologie und Geburtshilfe
Outcome results
None listed