Effect of different anesthetic regimens on the renoprotective effects of remote ischemic preconditioning (RIPC) in high- risk patients undergoing cardiac surgery

Effect of different anesthetic regimens on the renoprotective effects of remote ischemic preconditioning (RIPC) in high- risk patients undergoing cardiac surgery - HypnoRenalRIP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014989

Enrollment

160

Registered

2019-10-09

Start date

2018-06-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OPS-2013:5-35 (Operations on valves and septa of the heart and vessels near the heart, 5-361 (creation of an aortocoronary bypass) N17.99

Interventions

Group 1: total intravenous anesthesia + control (Sham-RIPC: 3 cycles of 5 min of pseudo ischemia (5 min blodd pressure cuff inflation to a pressure of 20 mm Hg and 5 min of cuff deflation) to the uppe

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with coronary heart disease and/ or heart valve disease and an increased risk for the development of a postoperative AKI (Cleveland score = 6) who have to undergo cardiac surgery with the use of the heart- lung machine. 2. Written informed consent of patient.

Exclusion criteria

Exclusion criteria: Acute myocardial infarction = 7 days before surgery age < 18 Off pump heart surgery Pre- existing AKI chronic kidney disease with eGFR < 30 ml/min Prior kidney transplant within the last 12 months Peripheral vascular disease affecting the upper limbs Pregnancy Hepatorenal syndrome Drug therapy with sulphonamide (incl. Thiazides) within the last 7 days Participation in another intervention study in the last 30 days Persons with any kind of dependency on the investigator or employed by the sponsor or investigator

Design outcomes

Primary

Measure	Time frame
Absolute changes in Biomarker levels (urinary TIMP*IGFBP7 postoperative (after RIPC/sham-RIPC intervention) minus preoperative (before RIPC/sham-RIPC intervention)).	—

Secondary

Measure	Time frame
- AKI within 72 h after cardiac surgery -MAKE on day 30 and day 90 (make = combined target criterion consisting of death, need for dialysis and persistent renal dysfunction (defined as increase in serum creatinins = 0.5 mg/dl via baseline) -MAKEmod on Day 30 and day 90 (MAKEmod = modified combined target criterion from death, need for dialysis and drop of eGFR by = 25% to baseline) -Renal recovery after acute kidney injury on day 30 and 90 (defined as ? serum creatinine < 0.5 mg/dl compared to baseline and a drop in eGFR < 25% or < 50%). -need for dialysis on Day 30 and day 90 -Mortality on day 30 and day 90	—

Measure

Time frame

- AKI within 72 h after cardiac surgery -MAKE on day 30 and day 90 (make = combined target criterion consisting of death, need for dialysis and persistent renal dysfunction (defined as increase in serum creatinins = 0.5 mg/dl via baseline) -MAKEmod on Day 30 and day 90 (MAKEmod = modified combined target criterion from death, need for dialysis and drop of eGFR by = 25% to baseline) -Renal recovery after acute kidney injury on day 30 and 90 (defined as ? serum creatinine < 0.5 mg/dl compared to baseline and a drop in eGFR < 25% or < 50%). -need for dialysis on Day 30 and day 90 -Mortality on day 30 and day 90

—

Countries

Germany

Contacts

Public ContactAlexander Zarbock

Klinik für Anästhesiologie, operative intensivmedizin und Schmerztherapie

aki@anit.uni-muenster.de02518347255

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026