Prospective evaluation of long-term effects after proton beam therapy on endocrine function of hypothalamus and pituitary gland in adults with brain and base of skull tumors

Prospective evaluation of long-term effects after proton beam therapy on endocrine function of hypothalamus and pituitary gland in adults with brain and base of skull tumors - EndoPro

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014873

Enrollment

130

Registered

2018-07-12

Start date

2019-03-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

endocrine function of hypothalamus and pituitary gland in brain and base of skull tumors

Interventions

Group 1: adults with brain and base of skull tumors receiving proton beam therapy. Evaluation of endocrine function.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age =18 years at the beginning of proton beam therapy - Diagnosis of a brain tumor or a tumor at the base of the skull - Proton beam therapy with justifying indication and consent to proton beam therapy - Written informed consent to participation in WPE’s Adult Registry Study (ProReg) - Written informed consent to the EndoPro study

Exclusion criteria

Exclusion criteria: - re-irradiation

Design outcomes

Primary

Measure	Time frame
Effect of radiation dose in proton beam therapy on endocrine function. Examination before the start of radiotherapy, 90 days after the end of treatment and further annually up to 5 years after the end of treatment.	—

Secondary

Measure	Time frame
overall sirvival and progression-free survival	—

Countries

Germany

Contacts

Public ContactSabine Frisch

Westdeutsches Protonentherapiezentrum Essen (WPE)

sabine.frisch@uk-essen.de0201/7236609

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026