G40
Conditions
Interventions
EEG, ECG and electrodermal activity sensors are used)
EEG, ECG and electrodermal activity sensors are used)
Group 2: healthy control group (resting state measurement before and after an exhaustive endurance test on an ergometer
Group 1: epilepsy group (resting state measurement before and after an exhaustive endurance test on an ergometer
Sponsors
Universität Paderborn Sportmedizinisches Institut
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Epilepsy group: diagnosed epilepsy (all epilepsy syndroms) Control group: healthy adult people
Exclusion criteria
Exclusion criteria: EPILEPSY GROUP • physical disabilities that preclude participation in a physical stress test • physical activity provoke epileptic seizures • cardiovascular diseases such as ischemic or structural heart disease o Myocardial diseases o Heart valve disorders (moderate to severe stenosis or insufficiency) o Congenital diseases o Arrhythmias o Hypertonic obstructive cardiomyopathy • myo-, endo-, pericarditis • cardiac surgery such as coronary angioplasty or revascularization surgery • moderate to severe hypertension • neurovascular or peripheral arterial disease • angina pectoris • severe pulmonary hypertension • thromboembolic processes • Blood coagulation disorders • Taking blood thinners, such as Marcumar • cardiac infarction • resting blood pressure of >220/120 mmHg • taking beta-blockers • brain lesions • acute feverish infections CONTROL GROUP • single epileptic seizure • physical disabilities that preclude participation in a physical stress test • cardiovascular diseases such as ischemic or structural heart disease o Myocardial diseases o Heart valve disorders (moderate to severe stenosis or insufficiency) o Congenital diseases o Arrhythmias o Hypertonic obstructive cardiomyopathy • myo-, endo-, pericarditis • cardiac surgery such as coronary angioplasty or revascularization surgery • moderate to severe hypertension • neurovascular or peripheral arterial disease • angina pectoris • severe pulmonary hypertension • thromboembolic processes • Blood coagulation disorders • Taking blood thinners, such as Marcumar • cardiac infarction • resting blood pressure of >220/120 mmHg • taking beta-blockers • brain lesions • acute feverish infections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spirometry parameters • Maximum oxygen consumption (VO2max) (Spirometry, Metalyzer 3B, CORTEX) a) during exercise test Parameters of the autonomic nervous system (ANS) • mean tonic electro dermal activity (EDA) (electro dermal wrist sensors, E4, Empatica) a) during resting state before and after exercise test b) during exercise test • “root mean square of successive differences” (RMSSD) (Elektrocardiogram, custo cardio 100 BT, custo med) a) during resting state before and after exercise test b) during exercise test Parameters of the electrical brain activity • functional connectivity (Electroenzephalogram, 128 actiCap Aktivelektroden, Brain Products) a) during resting state before and after exercise test | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular parameters (Electrocardiogram, custo cardio 100 BT, custo med) • mean heart rate a) during resting state before and after exercise test b) during each long increment (+recovery phase) • maximum heart rate • blood pressure a) during resting state before and after exercise test b) during each long increment (+recovery phase) Spirometry parameters • oxygen consumption (VO2) a) before the exercise test b) during each long increment (+recovery phase) • carbon dioxide release (VCO2) a) before the exercise test b) during each long increment (+recovery phase) c) maximum carbon dioxide release • respiratory minute volume (RMV) a) before the exercise test b) during each long increment (+recovery phase) c) maximum respiratory minute volume • maximum ventilatory equivalent for oxygen (max. VEq. = max. RMV/ max. VO2) • maximum ventilatory equivalent for carbon dioxid (max. VEq. = max. RMV/ max. VCO2) • maximum respiratory quotient (max. RQ = max. VCO2/ max. VO2) Parameters of the ANS • electro dermal response (EDR) (electro dermal wrist sensors, E4, Empatica) a) during resting state before and after exercise test b) during exercise test Other parameters: • total distance • stress test total duration (seconds) • maximum wattage • maximum metabolic equivalent (max. MET) • BORG-scale a) during resting state before and after exercise test b) before exercise test c) during each long increment (+recovery phase) • chronotropic reaction • chronotropic incompetence • double product • drug concentration (epilepsy group) • mean seizure frequency (medical history_epilepsy group) • clinical epidemiological parameters (medical history_epilepsy group/ medical history_control group) • physical activity (german version des „International Physical Activity Questionnaire“ (Craig et al. 2003)) | — |
Countries
Germany
Contacts
Public ContactFranziska van den Bongard
Universität Paderborn Sportmedizinisches Institut
Outcome results
None listed