D47.2
Conditions
Interventions
Group 1: 24 weeks of whole body vibration, 2x20min per week
Sponsors
Medizinische Klinik und Poliklinik II Universitätsklinikum Würzburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Known MGUS M-protein concentration below 30 g/l
Exclusion criteria
Exclusion criteria: Recent fracture (12 months) Plasmacell disease (Amyloidosis) Neurlogical/neuromuscular/degenerative deficits Severe polyneuropathy Vertigo Metal implants in the long bones acute deep veine thrombosis (24 months) coronar artery disease pace maker acute arthritis heavy smokers (>20/d) alcoholism (>14 g/d)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in Bone Mineral Density in the tibial bone in the pQCT after 24 weeks of whole body vibration training | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the blood levels of bone remodeling blood parameters (Sklerostin, DKK-1, AP, FGF-23, Klotho, P1NP, Osteocalcin, NTX, PTH, Myostatin und CK) as well as changes in physical performance parameters: grip strength via handheld dynamometry, gait speed while walking, ground reaction forces on a special ground reaction force plate and muscle mass via bioimpedanceanalysis. Measurements will be taken before study start, after 12 and 24 weeks. | — |
Countries
Germany
Contacts
Public ContactJohanna Stromsdörfer
Medizinische Klinik und Poliklinik II Universitätsklinikum Würzburg
Outcome results
None listed