Healthy volunteers
Conditions
Interventions
Group 1: Arm 1 - 0.33 L Anthocyanin-rich blueberry / grape juice daily for 28 days. This is followed by a wash-out period of 10 days and a run-in phase of 7 days.
Group 2: Arm 1 - 0.33 L Anthocyanin-r
Sponsors
Institut für Ernährungswissenschaft
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: male and female healty
Exclusion criteria
Exclusion criteria: 1. Ingestion of antibiotics during the last 3 months, 2. Ingestion of supplements during the last 3 months, 3. chronic and acute metabolic diseases, 4. chronic inflammation and gastrointestinal diseases, 5. Ingestion of medicines that affect the intestinal flora, 6. Ingestion of supplements (vitamin and trace elements)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inhibition of tumor cell migration in vitro after application of plasma-isolated anthocyanins and metabolites. The endpoint is recorded after 28 days compared to day 1. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of metabotypes (UHPLC-/ESI-TRAP MS) and determination of alpha- and beta-diverstiy (Next Generation sequencing (16S rRNA)) before and after juice intake. The endpoint is recorded after 28 days compared to day 1. | — |
Countries
Germany
Contacts
Public ContactSabine Kuntz
Institut für Ernährungswissenschaft
Outcome results
None listed