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Endogenous pain modulation after intensive muscle exertion and during experimentally induced muscle pain: conditioned pain modulation and offset analgesia

Endogenous pain modulation after intensive muscle exertion and during experimentally induced muscle pain: conditioned pain modulation and offset analgesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00014755
Enrollment
42
Registered
2018-05-15
Start date
2018-06-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain-free young adults

Interventions

Group 1: One-time isometric muscle load for the back extensor muscle (max. 4 minutes Biering-Sörensen test followed by concentric/eccentric muscle load for the back extensor (individual maximum number

Sponsors

Universität zu Lübeck
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: healthy (pain free) male or female Age: 18-45 years

Exclusion criteria

Exclusion criteria: chronic pain disorder, acute pain (including headache, toothache, muscle ache, etc.), orthopaedic or other diagnosis that does not allow to perform a training stimulus, Pregnancy, neurological, psychiatric or psychological illness migraine (if more than 1-2 attacks per year)

Design outcomes

Primary

MeasureTime frame
Offset analgesia (thermode): 4 repeated measurements: Before the muscle load (1.), immediately afterwards (2.), 24 hours later (3.) and one week later (4.)

Secondary

MeasureTime frame
Conditioned pain modulation (test stimulus: pressure pain thresholds; conditioning stimulus: ice water); Exercise-induced hypoalgesia (pressure pain threshold) 4 repeated measurements: Before the muscle load (1.), immediately afterwards (2.), 24 hours later (3.) and one week later (4.)

Countries

Germany, Poland

Contacts

Public ContactTibor Szikszay

Universität zu Lübeck

tibor.szikszay@uni-luebeck.deTel + 49 451 3101 8541

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026