L20 L29.8
Conditions
Interventions
Group 1: 120 patients with CP (chronic pruritus) of different origin will be included (atopic dermatitis, brachioradial pruritus, notalgia paresthetica and uremic pruritus). A series of experimental t
Sponsors
Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with chronic pruritus (due to atopic dermatitis, brachioradial pruritus, notalgia paresthetica or uremic pruritus); minimum age 18 years; skin type I-IV (Fitzpatrick classification); caucasians;
Exclusion criteria
Exclusion criteria: Patients who cannot complete the questionnaires due to physical or psychiatric diseases or an insufficient understanding of the German language. Patients taking antipruritic drugs. Patients with an infection at the potential biopsy area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphological parameters: epidermal and dermal nerve fiber density, caliber deviations, branching, characterization of nerve fibers (myelin, neuropeptides, non-peptidergic markers, receptor expression) Functional parameters: pruritus intensity evoked by electrical stimulation, pruritus/pain intensity evoked by stimulation with cowhage Immunostaining: expression of pruritic mediators Gene expression: cutaneous global gene expression profiles, differential expression profiles Patient questionnaires: NeuroDerm questionnaire, 5PLQ, SF12, Beck´s Depression Inventory (BDI), Trait anxiety inventory (STAI-T), Self-Administered Comorbidity Questionnaire (SCQ), Brief Pain Inventory (BPI), Pain Catastrophizing Scale, Neuropathic pain symptom inventory (NPSI). Assessments will be performed once for each study pariticipant. | — |
Countries
Germany
Contacts
Public ContactKonstantin Agelopoulos
Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus (KCP)Universitätsklinikum Münster
Outcome results
None listed