I27.0 I27.20
Conditions
Interventions
Group 1: 40 Patients with precapillary PH will undergo the following examinations.
This will be done at daytime.
First of all a current cardiac MRI scan will be obtained.
Secondly all current symptom
with no abnormal findings in an electrocardiogram, echocardiogram and normal NT-BNP levels) will also undergo lung function tests and a diaphragm ultrasound examination.
Sponsors
Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Age > 18 years (no age limit) b. able to consent c. Diagnosis of Nizza class I or IV precapillary pumonary Hypertension according to the most recent Guidelines of the European Society of Cardiology (ESC); >12 weeks since the diagnosis of PH has been made; no hospitalisation for HF in the last 4 weeks; optimal medical therapy in accordance with the most recent Guidelines of the European Society of Cardiology (ESC) with no change in medication in the last 4 weeks and combination therapy for PAH -where there was no treatment with combination therapy in PAH patients then the reason must be documented
Exclusion criteria
Exclusion criteria: - secondary (postcapillary) pulmonary hypertension (mean pulmonary arterial hypertension > 25 mmHg; PCWP >15 mmHg) - other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe renal impairment - severe neurological pre-existing conditions such as stroke, especially brainstem infarction - intake of opioids - severe psychiatric pre-existing conditions - contraindications to (cardiac) magnetic resonance imaging (MRI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thickening Ratio on diaphragm ultrasound (n.U.) | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Severity Scale [points] 6 MWD [m], Medical Research Council Dyspnoea Scale [points], Borg Dyspnoea Scale, Minessota Living with Heart Failure Questionnaire [Points] -> the above mentioned parameters will be assessed using questionnaires Forced vital capacity [ml], FEV1/FVC [%] -> the above mentioned Parameters will be assessed using Standard lung function testing Rate of rise of diaphragmatic amplitude during tidal breathing on ultrasound [cm/sec], Rate of rise of diaphragmatic amplitude during Sniff maneuver on ultrasound, Rate of rise of diaphragmatic amplitude during maximal inspiration on ultrasound, diaphragm thickness after maximal inspiration on ultrasound [cm], diaphragm thickness after maximal exspiration on ultrasound, diaphragm thickness after tidal breathing on ultrasound [cm] -> the above mentioned Parameters will be assessed using diaphragm ultrasound right ventricular pumpfunction on a cardiac MRI scan [%] pO2 and pCO2 on capillary blood gas analysis [mmHG] | — |
Countries
Germany
Contacts
Public ContactJens Spiesshoefer
Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
Outcome results
None listed