K20 K21 T78.1
Conditions
Interventions
Group 1: Therapy branch 1: Targeted allergen Elimination (after allergological testing) + abstention of cow's milk
Group 2: Therapy branch 2: Empiric elimination of the 6 most frequent food allergens
Sponsors
Abteilung für Gastroenterologie und HepatologieKinderklinik Erlangen
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Pediatric patients including 18 years of age with clinical or laboratorial suspicion of eosinophilic esophagitis
Exclusion criteria
Exclusion criteria: - Other causes for esophageal eosinophilia like chronic inflammatory bowel disease or celiac diesase - Esophageal candidosis or infection with Herpes simplex - Present esophageal gastritis or esophageal Enteritis - Ongoing Treatment with immunosuppressive or immunomodulating substances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Identification ot the most effective treatment branch as assessed by histological criteria for disease remission - Identification of biomarkers and their applicability in childhood to reduce the frequency of gastroscopies for follow up | — |
Secondary
| Measure | Time frame |
|---|---|
| - Identification of tolerance mechanisms to predict the optimal time for reintroduction ot the eliminated food allergen - Applicability of allergological skin tests (sensitivity, specificity, positive and negative predictive value) in childhood EoE (Eosinophilic Esophagitis) - Evaluation whether a susccessful tratment of EoE has an iompact on improving pulmonary obstruction (bronchial asthma) in affected children | — |
Countries
Germany, Switzerland
Contacts
Public ContactAndré Hörning
Abteilung für Gastroenterologie und HepatologieKinderklinik Erlangen
Outcome results
None listed