Non-Invasive Electrocardiographic Imaging of Atrial Fibrosis Substrate in Patients with persistent Atrial Fibrillation

Non-Invasive Electrocardiographic Imaging of Atrial Fibrosis Substrate in Patients with persistent Atrial Fibrillation - AF-SUBSTRAT-MAP-study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014687

Enrollment

Registered

2018-10-22

Start date

2019-02-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I48

Interventions

Group 1: Patients admitted for first ablation therapy of symptomatic persistent AF (atrial fibrillation) are eligible for inclusion in the study. 1-30 days prior to ablation (if there are no contrain

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients age more or equal to 18 years for both sexes - First catheter ablation procedure for symptomatic persistent AF - Given and signed consent by the patient to participate to this study

Exclusion criteria

Exclusion criteria: - Paroxysmal or long persistent AF - Pregnancy - Specific exclusion criteria for MRI (Patients with following criteria will not undergo MRI, but can be included in the study for ECG-Imaging and catheter mapping of atrial Low Voltage Areas): Implanted Cardiac Devices (Pacemaker, ICD), Claustrophobia

Design outcomes

Primary

Measure	Time frame
- Spatial correlation between the distribution and extent of LVA (low voltage areas) and atrial regions of slow electrical conduction (due to increase fibrosis) on ECGI-Maps (the day before the procedure) and invasive atrial voltage maps (during the ablation)	—

Secondary

Measure	Time frame
- Spatial correlation between the distribution and extent of LVA and atrial regions of slow electrical conduction (due to increase fibrosis) on ECGI-Maps (the day before ablation) and loss of wall thickness and fat deposition at MRI (1-30 days before ablation). - Predictive value of the extent of atrial low voltage substrate (assessed by ECGI vs invasive voltage mapping vs loss of wall thickness and fat deposition at MRI) on arrhythmia recurrence rate 12 months after the AF ablation. Arrhythmia recurrence is defined as AF or atrial tachycardia lasting > 30 seconds in 24-72 hour holter recordings at 6 and 12 months follow-up after the AF ablation procedure.	—

Measure

Time frame

- Spatial correlation between the distribution and extent of LVA and atrial regions of slow electrical conduction (due to increase fibrosis) on ECGI-Maps (the day before ablation) and loss of wall thickness and fat deposition at MRI (1-30 days before ablation). - Predictive value of the extent of atrial low voltage substrate (assessed by ECGI vs invasive voltage mapping vs loss of wall thickness and fat deposition at MRI) on arrhythmia recurrence rate 12 months after the AF ablation. Arrhythmia recurrence is defined as AF or atrial tachycardia lasting > 30 seconds in 24-72 hour holter recordings at 6 and 12 months follow-up after the AF ablation procedure.

—

Countries

Germany

Contacts

Public ContactAmir Jadidi

Universitäts-Herzzentrum Freiburg-Bad Krozingen - Klinik für Kardiologie und Angiologie II

Amir.Jadidi@universitaets-herzzentrum.de07633-402 4334

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026