M45.0 M07.3
Conditions
Interventions
Group 1: Blood and synovial fluid of patients with ankylosing spondylitis will be tested for cytokine production by ELISA and for immune cell phenotype by flow cytometry.
Synovial tissue from patients
Sponsors
Abteilung für Nephrologie, Klinikum rechts der Isar der TU München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of ankylosing spondylitis (modified New York criteria) or of psoriatric arthritis (CASPAR criteria) or of rheumatoid arthritis (EULAR/ACR criteria) Age > 18 years active disease no biologics (anti-TNF, anti-CD20) stable therapy regimen at recruitment
Exclusion criteria
Exclusion criteria: Failure of inclusion criteria active infections or malignancy other autoimmune disease surgery less than 2 weeks prior to study inclusion pregnancy patient not capable of consent; no consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of IL-26 in blood and synovial fluid of patients and controls measured by ELISA. Time point of measurement is identical with date of study inclusion. No longitudinal measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of IL-26 producing cell types in blood and synovial fluid at time of study entry by flow cytometry. Identification of IL-26 producing cells in synovial tissue at time of study entry by immunhistochemistry and -fluorescence. | — |
Countries
Germany
Contacts
Public ContactAriane Hammitzsch
Abteilung für Nephrologie, Klinikum rechts der Isar der TU München
Outcome results
None listed